Oncological Pharmacology, Angiogenesis and Personalized Medicine

The studies are addressed towards the understanding of cellular and molecular mechanisms of angiogenesis with particular regard to diseases related to inflammation, degenerative diseases and cancer. The characterization of new drugs and new pharmacological strategies for circumventing cancer drug resistance is also a topic in this area
Characterization of pro- and antiangiogenic factors in the disease progression and for therapeutic exploitation.
Assessment of molecular/metabolic biomarkers of cancer stemness and resistance to anticancer drugs
Pharmacological strategies for circumventing tumor drug resistance: novel inhibitors of ATP-dependent efflux transporters.
In vitro studies on anticancer effect of Rottlerin
Pharmacogenetics and personalized medicine in oncology
Researchers involved in the activities:
Erika Terzuoli https://www.researchgate.net/profile/Erika_Terzuoli
Lorenzo Bazzani https://it.linkedin.com/in/lorenzo-bazzani-113087123
Valerio Cicconehttps://it.linkedin.com/in/valerio-ciccone-0b45188a
Ginevra Nannelli https://it.linkedin.com/in/ginevra-nannelli-627b8b98
Filomena Costanza https://it.linkedin.com/in/filomena-costanza-4263aa12b
Docenti
Sandra Donnini
Maria Frosini
Francesca Ietta
Emanuela Maioli
Lucia Morbidelli
Simona Saponara
Marina Ziche
Research projects financed:
“Targeting the cancer resistome to restore tumor sensitivity through novel, existing and failed drugs”
PRIN (call 2015), Agency: Italian Ministry of Education, University and Research
Duration: 36 months (2017-2019), Principal Investigator: Lucia Morbidelli
Research Units:
Department of Chemical and Pharmaceutical Sciences, University of Trieste (Coordinator)
Department of Department of Pharmacy and Biotechnology, University of Bologna