Our research aims to deepen the understanding of the cellular and molecular mechanisms that regulate tumor angiogenesis, the process by which cancer cells stimulate the formation of new blood vessels to support their growth and spread. By studying the key factors involved in this process in the complex tumor microevironment, we seek to identify new therapeutic targets that could help inhibit abnormal blood vessel formation in tumors. Additionally, we focus on innovative strategies to overcome resistance to cancer therapies, a major challenge in oncology. This includes investigating the mechanisms that allow cancer cells to evade treatment, exploring novel drug combinations, and developing targeted therapies to improve the effectiveness of existing treatments. Our ultimate goal is to contribute to more precision and effective cancer therapies, reducing the impact of drug resistance and improving patient outcomes.
Key areas of investigation include:
- Exploring factors that promote or inhibit blood vessel formation in disease progression, with potential therapeutic applications.
- Identifying molecular and metabolic markers in tumor microenvironment that help cancer cells resist treatment.
- Developing new strategies to combat drug resistance in tumors, focusing on innovative inhibitors that block cancer cell defense mechanisms.
- Studying the anticancer effects of natural compounds, in laboratory models.
- Advancing precision medicine in oncology, using pharmacogenomics to tailor treatments to individual patients.