Project Title: Dual Delivery of NO and Sialidase Targeted Therapies to Stromal Rich Tumours
Key words: Nano drug delivery system, Breast Cancer, Immunoregulation, Therapeutics
Deadline is oct 21st
Abstract:
Stromal rich triple negative breast cancer (TNBC) demonstrate poor prognosis and are medically underserved for treatment options. Currently immune checkpoint inhibitor based therapies demonstrate limited efficacy. The reasons for this may include lack of immune cell infiltration, termed immune exclusion and also immunosuppression. Hypersialylation of stromal cells and the release of Nitric oxide (NO) has recently been shown to contribute to tumour growth and these features of immunosuppression and immune exclusion in TNBC.
The proposed project aims to address these limitations by delivering novel targeted therapeutics locally in stromal rich TNBC using a hydrogel based or nanoparticle delivery system.
8.2 Fellowship Funding Breakdown
The total gross remuneration costs for a Level 1 researcher without a family per month is €3703, and for a researcher with a family per month is €4271. The total gross remuneration costs for a Level 2 researcher without a family per month is €4351, and for a researcher with a family per month is €4920. Please note that all or part of these allowances will be liable for taxes and other deductions. e.g., the deduction of PRSI (employer social security (11.05%)) and, if applicable, pension (20%) contributions. The salary is fixed for 36 months of fellowship.
Level 1: €44,432 gross salary* per annum (excluding family allowance) or €51,256 gross salary* per annum (if conditions for family allowance are met)
Level 2: €52,213 gross salary* per annum (excluding family allowance) or €59,037 gross salary* per annum (if conditions for family allowance are met)