Molecular Toxicology

The main issue of the research in this area is the characterization of the molecular pathways  that lead to cellular injury induced by xenobiotics by different mechanisms such as oxidative stress or metabolic formation of reactive intermediate species.  The defence  exerted by antioxidants and glutathione-dependent mechanisms for detoxification of xenobiotics is also a research topic of this area. In vivo and in vitro studies on biodisposition of drugs and xenobiotics are also performed.
Role of cytochrome P450-dependent in hepatic and extrahepatic tissues. Interaction of xenobiotics with transporter(s) and drug metabolism system.
Identification of the most suitable biomarkers of oxidative stress.
Pharmacokinetics and pharmacodynamics of new drugs with antioxidant effect.
Role of  cytochrome P450 system in the xenobiotic metabolism in the dopamine neurones.
Molecular mechanisms involved in the toxicity of natural and synthetic chemicals (drugs, food contaminants, industrial, nanomaterials).
Lipidomic map in human cell lines upon long-term challenge of xenobiotics.
Nitric oxide (NO), S-nitrosothiols and NOx: study of their functions and metabolism.
Research Group
Aoife Bannon
Jesus Fernandez Abascal
Daniela Giustarini
Cosima Leone
Maria Frosini
Ranieri Rossi
Massimo Valoti
Research projects financed:
“Training in neurodegeneration, therapeutics intervention & neurorepair”
Grant agreement; Marie Curie, Initial Training Networks FP7-PEOPLE-2013-ITN,
Project acronym: TINTIN , Grant agreement no.: 608381; Duration 48 months (2014-2017) Principal Investigator: Massimo Valoti
Research Units:
Trinity College Dublin, Ireland (Coordinator)
University College London, UK
University of Salamanca; Spain
University of Manchester, UK
Mannhiem Central Institute for Mental Health, Germany
Kadir Has University, Istanbul, Turkey
“Biofilm management and cleaning by leveraging fundamental understanding of biological, chemical and physical combined approaches”
Grant agreement; Marie Curie, Innovative Training Networks H2020-MSCA-ITN-2016,
Project acronym: Bioclean,  Grant agreement no.: 722871; Principal Investigator: Ranieri Rossi.
Research Units
Procter & Gamble Technical Centres Limited, UK
Imperial College London, UK
University of Birmingham, UK
University of Bristol, UK
Katholieke Universiteit Leuven, Belgium
Consorzio Interunivesitario per lo Sviluppo dei Sistemi a Grande Interfase, Italy
Universiteit Gent, Belgium
Fraunhofer, Germany
Procter & Gamble Services Company N.V., Belgium
Procter & Gamble Services Company GmbH, Germany
AkzoNobel, UK
Itram Higiene S.L., Spain