Lucia MORBIDELLI

foto Lucia Morbidelli
Biosketch and CV

1988: Degree in Biological Sciences, Univ. Florence

1991: Specialist in Pharmacology, Univ. Florence

1996: PhD in Pharmacology and Toxicology, Univ. Florence

 

1988-91: Sandoz and Fidia fellowship

Nov. 1994-Feb. 95: Exchange Scientist, Case Western Reserve University (Cleveland, USA)

1996-97: Menarini fellowship

1998-99: post-doc, “Study of the cellular, biochemical and molecular mechanisms of angiogenesis"  (Univ. Florence)

2000-02: Post-doc, "Role of nitric oxide in the control of angiogenesis" (Univ. Siena)

Form Nov. 2002: Assistant Professor of Pharmacology

From July 2010: founder and manager of the spin-off  Noxamet srl

Research Interests
  • Pharmacology of gaseous transmitters (nitric oxide, hydrogen sulfide)
  • Evaluation of the role of nitric oxide and hydrogen sulfide pathways in cardiovascular pathophysiology and angiogenesis.
  • Preclinical characterization of synthetic and natural compounds in the modulation of vascular functions and physiologic and pathologic angiogenesis
  • Characterization of mechanical stimuli and synthetic biomaterials on endothelial cell functions
Research Group

Martina Monti (Noxamet srl)

Federica Finetti

Lorenzo Bazzani

Teaching Activities

2012-2013 "Pharmacology", Biological Sciences 

2013-2014: “Molecular Pharmacology and Toxicology”, Molecular and Cellular Biology

Selected Publications
  1. Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD. Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis. Biochem. Pharmacol. 84(3), 303-11 (2012)
     
  2. Koika V, Zhou Z, Vasileiadis I, Roussos C, Finetti F, Monti M, Morbidelli L, Papapetropoulos A. PKG-I inhibition attenuates vascular endothelial growth factor-stimulated angiogenesis. Vascul. Pharmacol. 53(5-6), 215-22 (2010)
     
  3. Morbidelli L, Pyriochou A, Filippi S, Vasileiadis I, Roussos C, Zhou Z, Loutrari H, Waltenberger J, Stössel A, Giannis A, Ziche M, Papapetropoulos A. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298(3), R824-32(2010)
     
  4. Donnini S, Terzuoli E, Ziche M, Morbidelli L. Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk. J. Pharmacol. Exp. Ther. 332(3), 776-84 (2010).
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  6. Ziche M, Donnini S, Morbidelli L, Monzani E, Roncone R, Gabbini R, Casella L.  Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation. ChemMedChem. 3(7), 1039-47 (2008)
     
  7. Pezzatini S, Morbidelli L, Solito R, Paccagnini E, Boanini E, Bigi A, Ziche M. Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis. Bone 41(4), 523-34 (2007)
     
  8. Donnini S, Solito R, Giachetti A, Granger HJ, Ziche M, Morbidelli L. Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium. J. Pharmacol. Exp. Ther. 319(2), 515-22 (2006)
     
  9. Donnini S, Finetti F, Lusini L, Morbidelli L, Cheynier V, Barron D, Williamson G, Waltenberger J, Ziche M. Divergent effects of quercetin conjugates on angiogenesis. Br. J. Nutr. 95(5), 1016-23 (2006)
     
  10. Morbidelli L, Donnini S, Filippi S, Messori L, Piccioli F, Orioli P, Sava G, Ziche M. Antiangiogenic properties of selected ruthenium(III) complexes that are  nitric oxide scavengers. Br. J. Cancer. 88(9), 1484-91 (2003)
     
  11. Parenti A, Morbidelli L, Ledda F, Granger HJ, Ziche M. The bradykinin/B1 receptor promotes angiogenesis by up-regulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway. FASEB J. 15(8), 1487-9 (2001).