Direttore Luca BINI

Luca Bini
Biosketch and CV

Luca Bini is Prof of Biochemistry and Proteome Sciences. He graduated in Biology before completing a PhD in Biotechnology. He spent some periods at the Geneva University (Switzerland) where he learned basic proteomic technologies. He is internationally well known as a contributor to the foundation of proteome science and he is the responsible of the Functional Proteomics lab. at the Siena University. Prof. Bini is one of the founders of the European Proteomics Association as well as of the Italian Proteomics Association and he is on the editorial boards of several leading proteomics journals.

Research Interests

Proteomic analysis of clinical specimens in different physio-pathological conditions (breast, stomach and lung cancer, lung fibrosis, acute phase, cellular differentiation and signaling, apoptosis, etc..) to identify specific markers.

Characterization of post-translational modifications (phosphorylation, oxidation, glycosilation).


Study of the immunproteome of infectious diseases, as well as of the immuneresponse in autoimmune diseases.


Functional proteomic investigation on some rare diseases such as Osteogenesis imperfecta, Cystic fibrosis and Krabbe disease.


Study of drug effects in culture cell lines, tissues and body fluids.


Determination of nanoparticle and microvesicle effects on different biological samples.


Teaching Activities

Currently, the main teaching activities of Prof. Bini are in the following courses:

Chimica Biologica (Biochemistry); Corso di Laurea in Scienze Biologiche, Università di Siena.

Scienza del Proteoma (Proteome Sciences); Corso di Laurea Magistrale in Biologia Molecolare e Cellulare, Università di Siena.

Selected Publications

Gistelinck C, Gioia R, Gagliardi A, Tonelli F, Marchese L, Bianchi L, Landi C, Bini L, Huysseune A, Witten PE, Staes A, Gevaert K, De Rocker N, Menten B, Malfait F, Leikin S, Carra S, Tenni R, Rossi A, De Paepe A, Coucke P, Willaert A, Forlino A.: Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Sci Rep.,6:21540 (2016).

Bianchi L, Gagliardi A, Maruelli S, Besio R, Landi C, Gioia R, Kozloff K M, Khoury B M, Coucke P J, Symoens S, Marini J C, Rossi A, Bini L, Forlino A.: Altered cytoskeletal organization characterized lethal but not surviving Brtl+/- mice: insight on phenotypic variability in osteogenesis imperfecta. Hum Mol Genet., 24, 6118-6133 (2015).

Landi C, Bargagli E, Carleo A, Bianchi L, Gagliardi A, Prasse A, Perari MG, Refini RM, Bini L, Rottoli P. A system biology study of BALF from patients affected by idiopathic pulmonary fibrosis (IPF) and healthy controls. Proteomics. Clinical Applications, 8, 932 – 950 (2014).

Gamberi T, Massai L, Magherini F, Landini I, Fiaschi T, Scaletti F, Gabbiani C, Bianchi L, Bini L, Nobili S, Perrone G, Mini E, Messori L, Modesti A. Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipy(c).. J. Proteomics, 103,. 103-120 (2014).

Bianchi L, Gagliardi A, Campanella G, Landi C, Capaldo A, Carleo A, Armini A, De Leo V, Piomboni P, Focarelli R, Bini L.: A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation. J Proteomics., 90, 61-76 (2013).

Landi C, Bargagli E, Bianchi L, Gagliardi A, Carleo A, Bennett D, Perari MG, Armini A, Prasse A, Rottoli P, Bini L.: “Towards a functional proteomics approach to the comprehension of idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis and pulmonary Langerhans cell histiocytosis”. J Proteomics. 2013, 83, 60-75 (2013).

Chillà A, Magherini F, Margheri F, Laurenzana A, Gamberi T, Bini L, Bianchi L, Danza G, Mazzanti B, Serratí S, Modesti A, Del Rosso M, Fibbi G.: “Proteomic identification of VEGF-dependent protein enrichment to membrane caveolar-raft microdomains in endothelial progenitor cells”. Mol Cell Proteomics, 12, 1926-38 (2013).

Gimigliano A., Mannini L., Bianchi L., Puglia M., Deardorff M.A., Menga S., Krantz I.D., Musio A., Bini L. Proteomic Profile Identifies Dysregulated Pathways in Cornelia de Lange Syndrome Cells With Distinct Mutations in SMC1A and SMC3 Genes. J. Proteome Res. 11, 6111-6123 (2012).

Bianchi L., Gagliardi A., Gioia R., Besio R., Tani C., Landi C., Cipriano M., Gimigliano A., Rossi A., Marini J.C., Forlino A., Bini L. Differential response to intracellular stress in the skin from osteogenesis imperfecta Brtl mice with lethal and non lethal phenotype: A proteomic approach. J. Proteomics 75, 4717-4733 (2012).

T. Gamberi, M. Puglia, L. Bianchi, A. Gimigliano, C. Landi, F. Magherini, F. Guidi, F. Ranaldi, A. Armini, M. Cipriano, A. Gagliardi, A. Modesti, L. Bini: “Evaluation of SCO1 deletion on Saccharomyces cerevisiae metabolism through a proteomic approach”. Proteomics, Vol. 12, 1767-1780 (2012).