1977 High School Graduated in Industrial Chemistry ( Institute of Industrial and Technical Chemistry “Tito Sarrocchi”, Siena , Italy).
2005 agro-food tecnologist qualification, with experimental thesis:” molecular characterization through microsatellites of Tuscan genotypes of olea europea” in professional course “genetic analysis and traceability of agri-food supply chains” organized by ARSIA Regione Toscana
Feb.1983/Apr 2001 Technical Assistant at the Institute of Pharmacological Sciences, University of Siena, Italy.
May 2001/Apr 2009 Technical Officer at the Department of Biomedical Sciences, University of Siena, Italy
May 2009/Nov 2012 Technical Officer at the Department of Neuroscineces, University of Siena, Italy
Dec 2012-present Research technician at the Department of Sciences of Life, University of Siena, Italy
Cardiovascular liabilities of novel multidrug resistance reverting agents and antineoplastic drugs (in vitro; ex vivo)
Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S . Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem, 59, 2612−2632. (2016)
Fusi F, Durante M, Gorelli B, Perrone MG, Colabufo N, Saponara S . MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation. J Cardiovasc Pharmacol. 70:405-410. (2017)
Vallone A, D'Alessandro S, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen KJM, Dechering KJ, Saponara S, Fusi F, Gorelli B, Taramelli D, Parapini S, Caldelari R, Campiani G, Gemma S, Butini S . Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues. Eur J Med Chem, 150:698-718. (2018)
Pessina F, Gamberucci A, Chen J, Liu B, Vangheluwe P, Gorelli B, Lorenzini S, Spiga O, Trezza A, Sgaragli G, Saponara S. Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak. Biochem Pharmacol, 155: 434-443. (2018)
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