Cosima T Baldari obtained her degree in Biological Sciences from the University of Rome in 1976. She did a postdoctoral fellowship at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. She joined the University of Rome in 1981 as staff scientist, returning to EMBL as visiting scientist in 1983. In 1986 she moved to the University of Siena, where she set up her research group and pursued her academic career first as Associate Professor and since 2000 as Full Professor. She is Chair of the Department of Life Sciences and member of the Academic Senate. She is a member of the European Molecular Biology Organization (EMBO) and AcademiaNet.
The activity of the lab is focused on the functional dissection of signal transduction pathways in lymphocyte activation and apoptosis and dysregulation of these processes un lymphoproliferative, immunodeficiency and pathogen-related diseases.
Current research topics include:
- Characterization of the Shc family of protein adapters in the immune system, with a focus on their role as negative regulators of autoimmunity and leukemia
- Regulation of membrane trafficking at the immune synapse by the intraflagellar transport system
- Modulation of antigen receptor signaling and immune synapse assembly by bacterial toxins as a strategy of immune evasion
Maria Teresa Savino
First level Biological Sciences graduate course on "Cell Proliferation and Signal Transduction"
Second level Molecular and Cellular Biology graduate course on "Molecular Biology of the Immune Response"
Boncristiano M, Rossi Paccani S, Barone S, Ulivieri C, Patrussi L, Ilver D, Amedei A, D'Elios MM, Telford JL, Baldari CT. The Helicobacter pylori vacuolating toxin inhibits T-cell activation by two independent mechanisms. J Exp Med 198, 1887-1897 (2003).
Rossi Paccani S, Tonello F, Ghittoni R, Natale M, Muraro L, D'Elios MM, Tang W-J, Montecucco C, Baldari CT. Anthrax toxins suppress T-lymphocyte activation by disrupting antigen receptor signaling. J Exp Med 201, 325-331 (2005).
Patrussi L, Ulivieri C, Lucherini OM, Rossi Paccani S, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT. p52Shc is required for CXCR4-dependent signaling and chemotaxis in T-cells. Blood 110, 1730-1738 (2007).
Finetti F, Pellegrini M, Ulivieri C, Savino MT, Paccagnini E, Ginanneschi C, Lanfrancone L, Pelicci PG, Baldari CT. The proapoptotic and antimitogenic protein p66Shc acts as a negative regulator of lymphocyte activation and autoimmunity. Blood 111, 5017-5027 (2008).
Rossi Paccani S, Benagiano M, Tonello F, Capitani N, Ladant D, Montecucco C, D'Elios MM, Baldari CT. The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell differentiation by shaping T cell antigen receptor signaling. PLoS Path 5, e1000325 (2009).
Finetti F, Rossi Paccani S, Riparbelli MG, Giacomello E, Perinetti G, Pazour GJ, Rosenbaum J, Baldari CT. An intraflagellar transport component is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol 11, 1332-1339 (2009).
Capitani N, Lucherini OM, Sozzi E, Ferro M, Giommoni N, Finetti F, De Falco G, Cencini E, Raspadori D, Pelicci PG, Lauria F, Forconi F, Baldari CT. Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood 115, 3726-3736 (2010).
Rossi Paccani S, Finetti F, Davi M, Patrussi L, D’Elios MM, Ladant D, Baldari CT. The adenylate cyclase toxin of Bordetella pertussis binds to T cells via the integrin LFA-1 and induces its disengagement from the immune synapse. J Exp Med 208, 131-133 (2011).
Rossi Paccani S, Benagiano M, Savino, MT, Finetti F, Tonello F, D’Elios MM, Baldari CT. The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of Th17 cell development. J Allergy Clin Immunol. 127, 1635-1637 (2011).
Capitani N, Patrussi L, Trentin L, Lucherini OM, Cannizzaro E, Migliaccio E, Frezzato F, Gattazzo C, Forconi F, Pelicci PG, Semenzato G, Baldari CT. S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavourable prognosis. Blood 120, 4391-4399 (2012).